Cigarettes and Gastrointestinal Disorders
نویسنده
چکیده مقاله:
Background and Objectives: Smoking is an important risk factor for gastrointestinal disorders such as peptic ulcer, Crohn's disease and various cancers. The present study discusses the most important and known effects of smoking on the gastrointestinal tract. Method and Materials: This review uses the keywords Smoking, Gastrointestinal diseases, Inflammation and Cancer in the English databases like PubMed, Elsevier, Proquest, Google scholar, Google search engine and other websites as well as using keywords smoking, device disorders Digestion, inflammation and cancer were performed in SID and MagIran Persian databases. Results: Cigarette smoke has an inhibitory effect on the recovery and regeneration of the gastrointestinal tract due to its toxic constituents. Exposure to cigarette smoke is associated with increased apoptosis of epithelial cells, total dendritic cells, macrophages, CD4, and CD8T, along with unregulated mRNA expression in CCL9 and CCL20, which are important chemical triggers in the pathogenesis of Crohn's disease. Cigarette smoke accelerates colitis by IFN-YT and CD4 cells. Cigarette smoke can also cause oxidative stress and impair vasodilator function in chronic inflammatory microvascular disease, resulting in ischemia, ulceration, and fibrosis. In addition, smoking can induce a carcinogenic process in the GI tract through inflammation and release of several inflammatory mediators such as cytokines, TNF-a, IL-I, IL-6, chemokines, CXCLI and CXCL8. Conclusion: Smoking can cause pathogenic and carcinogenic processes in the GI tract. In other words, it leads to severe chronic inflammation and then spread of cancer to the inflamed areas. Careful mechanistic studies of the effects of smoking may be helpful in developing more effective treatments for various gastrointestinal disorders.
منابع مشابه
Gastrointestinal (GI) Disorders in Pregnancy
یکی از شکایات شایع دوران حاملگی، اختلالات معده ای روده ای (GI) است. اطلاع از میزان بروز و چگونگی اختلالات معده ای روده ای، نوع مراقبت از بیماران حامله را تعیین خواهد کرد. در این مقاله تغییرات فیزیولوژیک، بیماریهای عفونی، بیماریهای اتوایمون و تشکیل زخم در سیستم گوارشی دوران بارداری مورد بحث قرار گرفته است. هم چنین در مورد درمان و اثرات آنها روی جنین و نیز اثر حاملگی روی انواع اختلالات معدی روده...
متن کاملTreatment of Functional Gastrointestinal Disorders in Children and Future Challenges
Functional gastrointestinal disorders (FGIDs) are a common problem in children. These disorders in children are classified into the following categories according to the ROME III classification: Functional Dyspepsia, Irritable bowel syndrome (IBS), Abdominal Migraines, Childhood Functional abdominal pain (FAP), Childhood functional abdominal pain syndrome and functional constipation. FGIDs are ...
متن کاملGastrointestinal motility disorders and acupuncture.
During the last decades, numerous studies have been performed to investigate the effects and mechanisms of acupuncture or electroacupuncture (EA) on gastrointestinal motility and patients with functional gastrointestinal diseases. A PubMed search was performed on this topic and all available studies published in English have been reviewed and evaluated. This review is organized based on the gas...
متن کاملInterstitial Cystitis and Gastrointestinal Disorders
gastrointestinal disorders. Table 1 shows the results of a survey in the United States in which more than 6,000 IC patients were asked what disorders they had in association with their IC. Our own data on IC and Sjögren's syndrome have been added to this list. Two groups of gastrointestinal disorders are included in this list: irritable bowel syndrome and Crohn's disease/ulcerative colitis. Bot...
متن کاملFunctional macrophages and gastrointestinal disorders
Macrophages (MΦ) differentiate from blood monocytes and participate in innate and adaptive immunity. Because of their abilities to recognize pathogens and activate bactericidal activities, MΦ are always discovered at the site of immune defense. MΦ in the intestine are unique, such that in the healthy intestine, they possess complex mechanisms to protect the gut from inflammation. In these compl...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 10 شماره 1
صفحات 41- 47
تاریخ انتشار 2019-09
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی برای این مقاله ارائه نشده است
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023